I'm compiling inkscape aqua using macports. I'm using variants +aqua +no_x11, and also goes around the issue described in https://bugs.launchpad.net/inkscape/+bug/721424. I then end-up with an executable that seems to be working fine, until I try to save something to disk, using "save as...". A few tests:
When using "save" directly, all is fine, but as soon as I try to exit from the "save as..." GUI, with save or cancel, I get the following crash:
Program received signal EXC_BAD_ACCESS, Could not access memory.
Reason: 13 at address: 0x0000000000000000
0x00007fff863d5120 in objc_msgSend ()
(gdb) bt
#0 0x00007fff863d5120 in objc_msgSend ()
#1 0x00007fff88039504 in _DPSNextEvent ()
#2 0x00007fff880387a9 in -[NSApplication nextEventMatchingMask:untilDate:inMode:dequeue:] ()
#3 0x0000000101e05fcd in poll_func ()
#4 0x00000001022a8fa8 in g_main_context_iterate ()
#5 0x00000001022a92a5 in g_main_loop_run ()
#6 0x0000000101a029f0 in gtk_main ()
#7 0x00000001000306b0 in sp_main_gui ()
#8 0x000000010002fd2e in main ()
Could you provide details about your platform (OS X version, arch)?
Also, it would be helpful to add the versions of the main dependencies (like gtk+, glib, gtkmm and glibmm) used for your current build to the report (as MacPorts updates quite frequently and things might change with later versions).